Ultra-sensitive Sequencing Identifies High Prevalence of Clonal Hematopoiesis-Associated Mutations throughout Adult Life

Clonal hematopoiesis results from somatic mutations in hematopoietic stem cells, which give an advantage to mutant cells, driving their clonal expansion and potentially leading to leukemia. The acquisition of clonal hematopoiesis-driver mutations (CHDMs) occurs with normal aging and these mutations...

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Bibliografiset tiedot
Julkaisussa:Am J Hum Genet
Päätekijät: Acuna-Hidalgo, Rocio, Sengul, Hilal, Steehouwer, Marloes, van de Vorst, Maartje, Vermeulen, Sita H., Kiemeney, Lambertus A.L.M., Veltman, Joris A., Gilissen, Christian, Hoischen, Alexander
Aineistotyyppi: Artigo
Kieli:Inglês
Julkaistu: Elsevier 2017
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Article
Linkit:https://ncbi.nlm.nih.gov/pmc/articles/PMC5501773/
https://ncbi.nlm.nih.gov/pubmed/28669404
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ajhg.2017.05.013
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