Chemotherapy Resistant Human Acute Myeloid Leukemia Cells are Not Enriched for Leukemic Stem Cells but Require Oxidative Metabolism

Chemotherapy-resistant human acute myeloid leukemia (AML) cells are thought to be enriched in quiescent immature leukemic stem cells (LSCs). To validate this hypothesis in vivo, we developed a clinically relevant chemotherapeutic approach treating patient-derived xenograft (PDX) with cytarabine. Cyt...

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Pubblicato in:Cancer Discov
Autori principali: Farge, Thomas, Saland, Estelle, de Toni, Fabienne, Aroua, Nesrine, Hosseini, Mohsen, Perry, Robin, Bosc, Claudie, Sugita, Mayumi, Stuani, Lucille, Fraisse, Marine, Scotland, Sarah, Larrue, Clément, Boutzen, Héléna, Féliu, Virginie, Nicolau-Travers, Marie-Laure, Cassant-Sourdy, Stéphanie, Broin, Nicolas, David, Marion, Serhan, Nizar, Sarry, Audrey, Tavitian, Suzanne, Kaoma, Tony, Vallar, Laurent, Iacovoni, Jason, Linares, Laetitia K., Montersino, Camille, Castellano, Rémy, Griessinger, Emmanuel, Collette, Yves, Duchamp, Olivier, Barreira, Yara, Hirsch, Pierre, Palama, Tony, Gales, Lara, Delhommeau, François, Garmy-Susini, Barbara, Portais, Jean-Charles, Vergez, François, Selak, Mary A., Danet-Desnoyers, Gwenn, Carroll, Martin, Récher, Christian, Sarry, Jean-Emmanuel
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2017
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC5501738/
https://ncbi.nlm.nih.gov/pubmed/28416471
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/2159-8290.CD-16-0441
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