Structures of PGAM5 Provide Insight into Active Site Plasticity and Multimeric Assembly

PGAM5 is a mitochondrial membrane protein that functions as an atypical Ser/Thr phosphatase and is a regulator of oxidative stress response, necroptosis, and autophagy. Here we present several crystal structures of PGAM5 including the activating N-terminal regulatory sequences, providing a model for...

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Detalhes bibliográficos
Publicado no:Structure
Main Authors: Chaikuad, Apirat, Filippakopoulos, Panagis, Marcsisin, Sean R., Picaud, Sarah, Schröder, Martin, Sekine, Shiori, Ichijo, Hidenori, Engen, John R., Takeda, Kohsuke, Knapp, Stefan
Formato: Artigo
Idioma:Inglês
Publicado em: Cell Press 2017
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5501728/
https://ncbi.nlm.nih.gov/pubmed/28648608
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.str.2017.05.020
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