Rhomboid Protease PARL Mediates the Mitochondrial Membrane Potential Loss-induced Cleavage of PGAM5

Regulated intramembrane proteolysis is a widely conserved mechanism for controlling diverse biological processes. Considering that proteolysis is irreversible, it must be precisely regulated in a context-dependent manner. Here, we show that phosphoglycerate mutase 5 (PGAM5), a mitochondrial Ser/Thr...

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Detalhes bibliográficos
Main Authors: Sekine, Shiori, Kanamaru, Yusuke, Koike, Masato, Nishihara, Ayako, Okada, Masahiro, Kinoshita, Hideyuki, Kamiyama, Miki, Maruyama, Junichi, Uchiyama, Yasuo, Ishihara, Naotada, Takeda, Kohsuke, Ichijo, Hidenori
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Biochemistry and Molecular Biology 2012
Assuntos:
Protein Synthesis and Degradation
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3464569/
https://ncbi.nlm.nih.gov/pubmed/22915595
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M112.357509
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