The immunoproteasome is induced by cytokines and regulates apoptosis in human islets

AIMS: In addition to degrading misfolded and damaged proteins, the proteasome regulates the fate of cells in response to stress. The role of the proteasome in pro-inflammatory cytokine-induced human beta-cell apoptosis is unknown. MATERIAL AND METHODS: INS-1, INS-1E and human islets were exposed to...

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Pubblicato in:J Endocrinol
Autori principali: Lundh, Morten, Bugliani, Marco, Dahlby, Tina, Chou, Danny Hung-Chieh, Wagner, Bridget, Ghiasi, Seyed Mojtaba, De Tata, Vincenzo, Chen, Zhifei, Lund, Marianne Nissan, Davies, Michael J., Marchetti, Piero, Mandrup-Poulsen, Thomas
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2017
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC5501413/
https://ncbi.nlm.nih.gov/pubmed/28438776
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1530/JOE-17-0110
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