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Metabolic labeling in middle-down proteomics allows for investigation of the dynamics of the histone code

BACKGROUND: Middle-down mass spectrometry (MS), i.e., analysis of long (~50–60 aa) polypeptides, has become the method with the highest throughput and accuracy for the characterization of combinatorial histone posttranslational modifications (PTMs). The discovery of histone readers with multiple dom...

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Bibliografski detalji
Izdano u:Epigenetics Chromatin
Glavni autori: Sidoli, Simone, Lu, Congcong, Coradin, Mariel, Wang, Xiaoshi, Karch, Kelly R., Ruminowicz, Chrystian, Garcia, Benjamin A.
Format: Artigo
Jezik:Inglês
Izdano: BioMed Central 2017
Teme:
Online pristup:https://ncbi.nlm.nih.gov/pmc/articles/PMC5501349/
https://ncbi.nlm.nih.gov/pubmed/28683815
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s13072-017-0139-z
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