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Effects of Aging and Niche Microenvironment on Spermatogonial Stem Cell Self-Renewal

Aging is evident in most tissues and organ systems, but the mechanisms of aging are difficult to identify and poorly understood. Here, we test the hypothesis that aging results in uncorrected defects in stem cell and/or niche function, which lead to system failure. We used the spermatogonial stem ce...

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Bibliographic Details
Published in:Stem Cells
Main Authors: Ryu, Buom-Yong, Orwig, Kyle E., Oatley, Jon M., Avarbock, Mary R., Brinster, Ralph L.
Format: Artigo
Language:Inglês
Published: 2006
Subjects:
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC5501308/
https://ncbi.nlm.nih.gov/pubmed/16456131
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1634/stemcells.2005-0580
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