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Effects of Aging and Niche Microenvironment on Spermatogonial Stem Cell Self-Renewal

Aging is evident in most tissues and organ systems, but the mechanisms of aging are difficult to identify and poorly understood. Here, we test the hypothesis that aging results in uncorrected defects in stem cell and/or niche function, which lead to system failure. We used the spermatogonial stem ce...

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Библиографические подробности
Опубликовано в: :Stem Cells
Главные авторы: Ryu, Buom-Yong, Orwig, Kyle E., Oatley, Jon M., Avarbock, Mary R., Brinster, Ralph L.
Формат: Artigo
Язык:Inglês
Опубликовано: 2006
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Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC5501308/
https://ncbi.nlm.nih.gov/pubmed/16456131
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1634/stemcells.2005-0580
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