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Effects of Aging and Niche Microenvironment on Spermatogonial Stem Cell Self-Renewal

Aging is evident in most tissues and organ systems, but the mechanisms of aging are difficult to identify and poorly understood. Here, we test the hypothesis that aging results in uncorrected defects in stem cell and/or niche function, which lead to system failure. We used the spermatogonial stem ce...

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Publicat a:Stem Cells
Autors principals: Ryu, Buom-Yong, Orwig, Kyle E., Oatley, Jon M., Avarbock, Mary R., Brinster, Ralph L.
Format: Artigo
Idioma:Inglês
Publicat: 2006
Matèries:
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC5501308/
https://ncbi.nlm.nih.gov/pubmed/16456131
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1634/stemcells.2005-0580
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