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Effects of Aging and Niche Microenvironment on Spermatogonial Stem Cell Self-Renewal

Aging is evident in most tissues and organ systems, but the mechanisms of aging are difficult to identify and poorly understood. Here, we test the hypothesis that aging results in uncorrected defects in stem cell and/or niche function, which lead to system failure. We used the spermatogonial stem ce...

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Detalhes bibliográficos
Publicado no:Stem Cells
Main Authors: Ryu, Buom-Yong, Orwig, Kyle E., Oatley, Jon M., Avarbock, Mary R., Brinster, Ralph L.
Formato: Artigo
Idioma:Inglês
Publicado em: 2006
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5501308/
https://ncbi.nlm.nih.gov/pubmed/16456131
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1634/stemcells.2005-0580
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