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SYK licenses MyD88 to instigate IL-1α-mediated inflammatory disease
Mice carrying a hypomorphic point mutation in the Ptpn6 gene (Ptpn6(spin) mice) develop an inflammatory skin disease that resembles neutrophilic dermatosis in humans. Here, we demonstrated that interleukin (IL)-1α signaling through IL-1R and MyD88 in both stromal and immune cells drive inflammation...
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| Publicado en: | Immunity |
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| Main Authors: | , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado: |
2017
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| Assuntos: | |
| Acceso en liña: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5501252/ https://ncbi.nlm.nih.gov/pubmed/28410990 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.immuni.2017.03.014 |
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