Drug discovery for Diamond-Blackfan anemia using reprogrammed hematopoietic progenitors

Diamond-Blackfan anemia (DBA) is a congenital disorder characterized by the failure of erythroid progenitor differentiation, severely curtailing red blood cell production. Because many DBA patients fail to respond to corticosteroid therapy, there is considerable need for therapeutics for this disord...

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Publicado en:Sci Transl Med
Main Authors: Doulatov, Sergei, Vo, Linda T., Macari, Elizabeth R., Wahlster, Lara, Kinney, Melissa A., Taylor, Alison M., Barragan, Jessica, Gupta, Manav, McGrath, Katherine, Lee, Hsiang-Ying, Humphries, Jessica M., DeVine, Alex, Narla, Anupama, Alter, Blanche P., Beggs, Alan H., Agarwal, Suneet, Ebert, Benjamin L., Gazda, Hanna T., Lodish, Harvey F., Sieff, Colin A., Schlaeger, Thorsten M., Zon, Leonard I., Daley, George Q.
Formato: Artigo
Idioma:Inglês
Publicado: 2017
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Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC5501179/
https://ncbi.nlm.nih.gov/pubmed/28179501
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/scitranslmed.aah5645
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