Calmodulin inhibitors improve erythropoiesis in Diamond-Blackfan anemia

Diamond-Blackfan anemia (DBA) is a rare hematopoietic disease characterized by a block in red cell differentiation. Most DBA cases are caused by mutations in ribosomal proteins and characterized by higher than normal activity of the tumor suppressor p53. Higher p53 activity is thought to contribute...

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Published in:Sci Transl Med
Main Authors: Taylor, Alison M., Macari, Elizabeth R., Chan, Iris T., Blair, Megan C., Doulatov, Sergei, Vo, Linda T., Raiser, David M., Siva, Kavitha, Basak, Anindita, Pirouz, Mehdi, Shah, Arish N., McGrath, Katherine, Humphries, Jessica M., Stillman, Emma, Alter, Blanche P., Calo, Eliezer, Gregory, Richard I., Sankaran, Vijay G., Flygare, Johan, Ebert, Benjamin L., Zhou, Yi, Daley, George Q., Zon, Leonard I.
Format: Artigo
Language:Inglês
Published: 2020
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Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC7709865/
https://ncbi.nlm.nih.gov/pubmed/33087503
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/scitranslmed.abb5831
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