Oncogenic signaling by Kit tyrosine kinase occurs selectively on the Golgi apparatus in gastrointestinal stromal tumors

Gastrointestinal stromal tumors (GISTs) are caused by gain-of-function mutations in the Kit receptor tyrosine kinase. Most primary GIST patients respond to the Kit inhibitor imatinib, but this drug often becomes ineffective because of secondary mutations in the Kit kinase domain. The characteristic...

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Библиографические подробности
Опубликовано в: :Oncogene
Главные авторы: Obata, Y, Horikawa, K, Takahashi, T, Akieda, Y, Tsujimoto, M, Fletcher, J A, Esumi, H, Nishida, T, Abe, R
Формат: Artigo
Язык:Inglês
Опубликовано: Nature Publishing Group 2017
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Original Article
Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC5500841/
https://ncbi.nlm.nih.gov/pubmed/28192400
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/onc.2016.519
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