N822K- or V560G-mutated KIT activation preferentially occurs in lipid rafts of the Golgi apparatus in leukemia cells

BACKGROUND: KIT tyrosine kinase is expressed in mast cells, interstitial cells of Cajal, and hematopoietic cells. Permanently active KIT mutations lead these host cells to tumorigenesis, and to such diseases as mast cell leukemia (MCL), gastrointestinal stromal tumor (GIST), and acute myeloid leukem...

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Detalhes bibliográficos
Publicado no:Cell Commun Signal
Main Authors: Obata, Yuuki, Hara, Yasushi, Shiina, Isamu, Murata, Takatsugu, Tasaki, Yasutaka, Suzuki, Kyohei, Ito, Keiichi, Tsugawa, Shou, Yamawaki, Kouhei, Takahashi, Tsuyoshi, Okamoto, Koji, Nishida, Toshirou, Abe, Ryo
Formato: Artigo
Idioma:Inglês
Publicado em: BioMed Central 2019
Assuntos:
Research
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6727407/
https://ncbi.nlm.nih.gov/pubmed/31484543
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s12964-019-0426-3
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