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Insights into the mechanism of cystatin C oligomer and amyloid formation and its interaction with β-amyloid
Cystatin C (CysC) is a versatile and ubiquitously-expressed member of the cysteine protease inhibitor family that is present at notably high concentrations in cerebrospinal fluid. Under mildly denaturing conditions, CysC forms inactive domain-swapped dimers. A destabilizing mutation, L68Q, increases...
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| Veröffentlicht in: | J Biol Chem |
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| Hauptverfasser: | , , |
| Format: | Artigo |
| Sprache: | Inglês |
| Veröffentlicht: |
American Society for Biochemistry and Molecular Biology
2017
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| Schlagworte: | |
| Online Zugang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5500812/ https://ncbi.nlm.nih.gov/pubmed/28487367 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M117.786558 |
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