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Ion Channel Formation by Amyloid-β(42) Oligomers but Not Amyloid-β(40) in Cellular Membranes
A central hallmark of Alzheimer's disease is the presence of extracellular amyloid plaques chiefly consisting of amyloid-β (Aβ) peptides in the brain interstitium. Aβ largely exists in two isoforms, 40 and 42 amino acids long, but a large body of evidence points to Aβ(1–42) rather than Aβ(1–40)...
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| Опубликовано в: : | J Biol Chem |
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| Главные авторы: | , , |
| Формат: | Artigo |
| Язык: | Inglês |
| Опубликовано: |
American Society for Biochemistry and Molecular Biology
2017
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| Предметы: | |
| Online-ссылка: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5270483/ https://ncbi.nlm.nih.gov/pubmed/27927987 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M116.762526 |
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