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A dock and coalesce mechanism driven by hydrophobic interactions governs Cdc42 binding with its effector protein ACK
Cdc42 is a Rho-family small G protein that has been widely studied for its role in controlling the actin cytoskeleton and plays a part in several potentially oncogenic signaling networks. Similar to most other small G proteins, Cdc42 binds to many downstream effector proteins to elicit its cellular...
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| Udgivet i: | J Biol Chem |
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| Main Authors: | , , , |
| Format: | Artigo |
| Sprog: | Inglês |
| Udgivet: |
American Society for Biochemistry and Molecular Biology
2017
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| Fag: | |
| Online adgang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5500802/ https://ncbi.nlm.nih.gov/pubmed/28539360 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M117.789883 |
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