Investigation of the Interaction between Cdc42 and Its Effector TOCA1: HANDOVER OF Cdc42 TO THE ACTIN REGULATOR N-WASP IS FACILITATED BY DIFFERENTIAL BINDING AFFINITIES

Transducer of Cdc42-dependent actin assembly protein 1 (TOCA1) is an effector of the Rho family small G protein Cdc42. It contains a membrane-deforming F-BAR domain as well as a Src homology 3 (SH3) domain and a G protein-binding homology region 1 (HR1) domain. TOCA1 binding to Cdc42 leads to actin...

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Detalhes bibliográficos
Publicado no:J Biol Chem
Main Authors: Watson, Joanna R., Fox, Helen M., Nietlispach, Daniel, Gallop, Jennifer L., Owen, Darerca, Mott, Helen R.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Biochemistry and Molecular Biology 2016
Assuntos:
Signal Transduction
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4919469/
https://ncbi.nlm.nih.gov/pubmed/27129201
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M116.724294
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