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Progress in the therapeutic inhibition of Cdc42 signalling

Cdc42 is a member of the Rho family of small GTPases and a key regulator of the actin cytoskeleton, controlling cell motility, polarity and cell cycle progression. It signals downstream of the master regulator Ras and is essential for cell transformation by this potent oncogene. Overexpression of Cd...

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Bibliografski detalji
Izdano u:Biochem Soc Trans
Glavni autori: Murphy, Natasha P., Mott, Helen R., Owen, Darerca
Format: Artigo
Jezik:Inglês
Izdano: Portland Press Ltd. 2021
Teme:
Online pristup:https://ncbi.nlm.nih.gov/pmc/articles/PMC8286826/
https://ncbi.nlm.nih.gov/pubmed/34100887
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1042/BST20210112
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