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Structure-based prediction of Wnt binding affinities for Frizzled-type cysteine-rich domains

Wnt signaling pathways are of significant interest in development and oncogenesis. The first step in these pathways typically involves the binding of a Wnt protein to the cysteine-rich domain (CRD) of a Frizzled receptor. Wnt-Frizzled interactions can be antagonized by secreted Frizzled-related prot...

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Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Cyhoeddwyd yn:J Biol Chem
Prif Awduron: Agostino, Mark, Pohl, Sebastian Öther-Gee, Dharmarajan, Arun
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: American Society for Biochemistry and Molecular Biology 2017
Pynciau:
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC5500790/
https://ncbi.nlm.nih.gov/pubmed/28533339
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M117.786269
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