Amyloid-β Binds to the Extracellular Cysteine-rich Domain of Frizzled and Inhibits Wnt/β-Catenin Signaling

The amyloid-β peptide (Aβ) plays a major role in neuronal dysfunction and neurotoxicity in Alzheimer disease. However, the signal transduction mechanisms involved in Aβ-induced neuronal dysfunction remain to be fully elucidated. A major current unknown is the identity of the protein receptor(s) invo...

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Bibliographic Details
Main Authors: Magdesian, Margaret H., Carvalho, Milena M. V. F., Mendes, Fabio A., Saraiva, Leonardo M., Juliano, Maria A., Juliano, Luiz, Garcia-Abreu, José, Ferreira, Sérgio T.
Format: Artigo
Language:Inglês
Published: American Society for Biochemistry and Molecular Biology 2008
Subjects:
Molecular Basis of Cell and Developmental Biology
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC2431018/
https://ncbi.nlm.nih.gov/pubmed/18234671
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M707108200
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