Mechanistic clues to the protective effect of chrysin against doxorubicin-induced cardiomyopathy: Plausible roles of p53, MAPK and AKT pathways

Doxorubicin (DOX) is the mainstay chemotherapeutic agent against a variety of human neoplasmas. However, its clinical utility is limited by its marked cardiotoxicity. Chrysin, is a natural flavone which possesses antioxidant, anti-inflammatory and anti-cancer properties. The current study aimed to i...

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Vydáno v:Sci Rep
Hlavní autoři: Mantawy, Eman M., Esmat, Ahmed, El-Bakly, Wesam M., Salah ElDin, Rania A., El-Demerdash, Ebtehal
Médium: Artigo
Jazyk:Inglês
Vydáno: Nature Publishing Group UK 2017
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Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC5500480/
https://ncbi.nlm.nih.gov/pubmed/28684738
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-017-05005-9
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