Genetic Determinants of 1,3-Butadiene Metabolism and Detoxification in Three Populations of Smokers with Different Risks of Lung Cancer

BACKGROUND: 1,3-Butadiene (BD) is an important carcinogen in tobacco smoke that undergoes metabolic activation to DNA-reactive epoxides. These species can be detoxified via glutathione conjugation and excreted in urine as the corresponding N-acetylcysteine conjugates. We hypothesize that single nucl...

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Vydáno v:Cancer Epidemiol Biomarkers Prev
Hlavní autoři: Boldry, Emily J., Patel, Yesha M., Kotapati, Srikanth, Esades, Amanda, Park, Lani, Tiirikainen, Maarit, Stram, Daniel, Le Marchand, Loïc, Tretyakova, Natalia
Médium: Artigo
Jazyk:Inglês
Vydáno: 2017
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Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC5500389/
https://ncbi.nlm.nih.gov/pubmed/28292921
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/1055-9965.EPI-16-0838
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