Phosphorylation of the HIV-1 capsid by MELK triggers uncoating to promote viral cDNA synthesis

Regulation of capsid disassembly is crucial for efficient HIV-1 cDNA synthesis after entry, yet host factors involved in this process remain largely unknown. Here, we employ genetic screening of human T-cells to identify maternal embryonic leucine zipper kinase (MELK) as a host factor required for o...

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Enregistré dans:
Détails bibliographiques
Publié dans:PLoS Pathog
Auteurs principaux: Takeuchi, Hiroaki, Saito, Hideki, Noda, Takeshi, Miyamoto, Tadashi, Yoshinaga, Tomokazu, Terahara, Kazutaka, Ishii, Hiroshi, Tsunetsugu-Yokota, Yasuko, Yamaoka, Shoji
Format: Artigo
Langue:Inglês
Publié: Public Library of Science 2017
Sujets:
Research Article
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC5500366/
https://ncbi.nlm.nih.gov/pubmed/28683086
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.ppat.1006441
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