Patient-Specific iPSC Derived Endothelial Cells Uncover Pathways that Protect Against Pulmonary Hypertension in BMPR2 Mutation Carriers

In familial pulmonary arterial hypertension (FPAH) the autosomal dominant disease-causing BMPR2 mutation is only 20% penetrant, suggesting that genetic variation provides modifiers that alleviate the disease. Here, we used comparison of induced pluripotent stem cell derived endothelial cells (iPSC-E...

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Detalhes bibliográficos
Publicado no:Cell Stem Cell
Main Authors: Gu, Mingxia, Shao, Ning-Yi, Sa, Silin, Li, Dan, Termglinchan, Vittavat, Ameen, Mohamed, Karakikes, Ioannis, Sosa, Gustavo, Grubert, Fabian, Lee, Jaecheol, Cao, Aiqin, Taylor, Shalina, Ma, Yu, Zhao, Zhixin, Chappell, James, Hamid, Rizwan, Austin, Eric D., Gold, Joseph D, Wu, Joseph C, Snyder, Michael P, Rabinovitch, Marlene
Formato: Artigo
Idioma:Inglês
Publicado em: 2016
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5500296/
https://ncbi.nlm.nih.gov/pubmed/28017794
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.stem.2016.08.019
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