SeqA structures behind Escherichia coli replication forks affect replication elongation and restart mechanisms

The SeqA protein binds hemi-methylated GATC sites and forms structures that sequester newly replicated origins and trail the replication forks. Cells that lack SeqA display signs of replication fork disintegration. The broken forks could arise because of over-initiation (the launching of too many fo...

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Vydáno v:Nucleic Acids Res
Hlavní autoři: Pedersen, Ida Benedikte, Helgesen, Emily, Flåtten, Ingvild, Fossum-Raunehaug, Solveig, Skarstad, Kirsten
Médium: Artigo
Jazyk:Inglês
Vydáno: Oxford University Press 2017
Témata:
Genome Integrity, Repair and Replication
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC5499823/
https://ncbi.nlm.nih.gov/pubmed/28407100
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gkx263
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