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SeqA structures behind Escherichia coli replication forks affect replication elongation and restart mechanisms

The SeqA protein binds hemi-methylated GATC sites and forms structures that sequester newly replicated origins and trail the replication forks. Cells that lack SeqA display signs of replication fork disintegration. The broken forks could arise because of over-initiation (the launching of too many fo...

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Publicado en:Nucleic Acids Res
Autores principales: Pedersen, Ida Benedikte, Helgesen, Emily, Flåtten, Ingvild, Fossum-Raunehaug, Solveig, Skarstad, Kirsten
Formato: Artigo
Lenguaje:Inglês
Publicado: Oxford University Press 2017
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Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC5499823/
https://ncbi.nlm.nih.gov/pubmed/28407100
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gkx263
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