An RRM–ZnF RNA recognition module targets RBM10 to exonic sequences to promote exon exclusion

RBM10 is an RNA-binding protein that plays an essential role in development and is frequently mutated in the context of human disease. RBM10 recognizes a diverse set of RNA motifs in introns and exons and regulates alternative splicing. However, the molecular mechanisms underlying this seemingly rel...

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Detalhes bibliográficos
Publicado no:Nucleic Acids Res
Main Authors: Collins, Katherine M., Kainov, Yaroslav A., Christodolou, Evangelos, Ray, Debashish, Morris, Quaid, Hughes, Timothy, Taylor, Ian A., Makeyev, Eugene V., Ramos, Andres
Formato: Artigo
Idioma:Inglês
Publicado em: Oxford University Press 2017
Assuntos:
RNA
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5499739/
https://ncbi.nlm.nih.gov/pubmed/28379442
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gkx225
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