Fbxl19 recruitment to CpG islands is required for Rnf20-mediated H2B mono-ubiquitination

Histone H2B lysine 120 mono-ubiquitination (H2Bub1) catalyzed by Rnf20 has been implicated in normal differentiation of embryonic stem (ES) and adult stem cells. However, it remains unknown how Rnf20 is recruited to its specific target chromosomal loci for the establishment of H2Bub1. Here, we revea...

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Bibliographic Details
Published in:Nucleic Acids Res
Main Authors: Lee, Bum-Kyu, Lee, Jiwoon, Shen, Wenwen, Rhee, Catherine, Chung, Haewon, Kim, Jonghwan
Format: Artigo
Language:Inglês
Published: Oxford University Press 2017
Subjects:
Gene regulation, Chromatin and Epigenetics
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC5499583/
https://ncbi.nlm.nih.gov/pubmed/28453857
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gkx310
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