Interspecies NASH disease activity whole-genome profiling identifies a fibrogenic role of PPARα-regulated dermatopontin

Nonalcoholic fatty liver disease prevalence is soaring with the obesity pandemic, but the pathogenic mechanisms leading to the progression toward active nonalcoholic steatohepatitis (NASH) and fibrosis, major causes of liver-related death, are poorly defined. To identify key components during the pr...

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Pubblicato in:JCI Insight
Autori principali: Lefebvre, Philippe, Lalloyer, Fanny, Baugé, Eric, Pawlak, Michal, Gheeraert, Céline, Dehondt, Hélène, Vanhoutte, Jonathan, Woitrain, Eloise, Hennuyer, Nathalie, Mazuy, Claire, Bobowski-Gérard, Marie, Zummo, Francesco Paolo, Derudas, Bruno, Driessen, Ann, Hubens, Guy, Vonghia, Luisa, Kwanten, Wilhelmus J., Michielsen, Peter, Vanwolleghem, Thomas, Eeckhoute, Jérôme, Verrijken, An, Van Gaal, Luc, Francque, Sven, Staels, Bart
Natura: Artigo
Lingua:Inglês
Pubblicazione: American Society for Clinical Investigation 2017
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Research Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC5499370/
https://ncbi.nlm.nih.gov/pubmed/28679947
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/jci.insight.92264
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