Interspecies NASH disease activity whole-genome profiling identifies a fibrogenic role of PPARα-regulated dermatopontin

Nonalcoholic fatty liver disease prevalence is soaring with the obesity pandemic, but the pathogenic mechanisms leading to the progression toward active nonalcoholic steatohepatitis (NASH) and fibrosis, major causes of liver-related death, are poorly defined. To identify key components during the pr...

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izdano v:JCI Insight
Main Authors: Lefebvre, Philippe, Lalloyer, Fanny, Baugé, Eric, Pawlak, Michal, Gheeraert, Céline, Dehondt, Hélène, Vanhoutte, Jonathan, Woitrain, Eloise, Hennuyer, Nathalie, Mazuy, Claire, Bobowski-Gérard, Marie, Zummo, Francesco Paolo, Derudas, Bruno, Driessen, Ann, Hubens, Guy, Vonghia, Luisa, Kwanten, Wilhelmus J., Michielsen, Peter, Vanwolleghem, Thomas, Eeckhoute, Jérôme, Verrijken, An, Van Gaal, Luc, Francque, Sven, Staels, Bart
Format: Artigo
Jezik:Inglês
Izdano: American Society for Clinical Investigation 2017
Teme:
Research Article
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC5499370/
https://ncbi.nlm.nih.gov/pubmed/28679947
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/jci.insight.92264
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