Fibroblast deletion of ROCK2 attenuates cardiac hypertrophy, fibrosis, and diastolic dysfunction

Although left ventricular (LV) diastolic dysfunction is often associated with hypertension, little is known regarding its underlying pathophysiological mechanism. Here, we show that the actin cytoskeletal regulator, Rho-associated coiled-coil containing kinase-2 (ROCK2), is a critical mediator of LV...

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Bibliografiset tiedot
Julkaisussa:JCI Insight
Päätekijät: Shimizu, Toru, Narang, Nikhil, Chen, Phetcharat, Yu, Brian, Knapp, Maura, Janardanan, Jyothi, Blair, John, Liao, James K.
Aineistotyyppi: Artigo
Kieli:Inglês
Julkaistu: American Society for Clinical Investigation 2017
Aiheet:
Research Article
Linkit:https://ncbi.nlm.nih.gov/pmc/articles/PMC5499369/
https://ncbi.nlm.nih.gov/pubmed/28679962
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/jci.insight.93187
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