Matrix metalloproteinase-9 deletion attenuates myocardial fibrosis and diastolic dysfunction in ageing mice

AIMS: Age-related diastolic dysfunction has been attributed to an increased passive stiffness, which is regulated by extracellular matrix (ECM). We recently showed that matrix metalloproteinase (MMP)-9, an ECM mediator, increases in the left ventricle (LV) with age. The aim of this study, accordingl...

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Autors principals: Chiao, Ying Ann, Ramirez, Trevi A., Zamilpa, Rogelio, Okoronkwo, S. Michelle, Dai, Qiuxia, Zhang, Jianhua, Jin, Yu-Fang, Lindsey, Merry L.
Format: Artigo
Idioma:Inglês
Publicat: Oxford University Press 2012
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Original Articles
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC3500048/
https://ncbi.nlm.nih.gov/pubmed/22918978
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/cvr/cvs275
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