Adoptively transferred Vγ9Vδ2 T cells show potent antitumor effects in a preclinical B cell lymphomagenesis model

A central issue for adoptive cellular immunotherapy is overcoming immunosuppressive signals to achieve tumor clearance. While γδ T cells are known to be potent cytolytic effectors that can kill a variety of cancers, it is not clear whether they are inhibited by suppressive ligands expressed in tumor...

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Detalhes bibliográficos
Publicado no:JCI Insight
Main Authors: Zumwalde, Nicholas A., Sharma, Akshat, Xu, Xuequn, Ma, Shidong, Schneider, Christine L., Romero-Masters, James C., Hudson, Amy W., Gendron-Fitzpatrick, Annette, Kenney, Shannon C., Gumperz, Jenny E.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Clinical Investigation 2017
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5499361/
https://ncbi.nlm.nih.gov/pubmed/28679955
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/jci.insight.93179
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