Chemical activation of adenylyl cyclase Rv1625c inhibits growth of Mycobacterium tuberculosis on cholesterol and modulates intramacrophage signaling

Mycobacterium tuberculosis (Mtb) uses a complex 3′-5′-cyclic AMP (cAMP) signaling network to sense and respond to changing environments encountered during infection, so perturbation of cAMP signaling might be leveraged to disrupt Mtb pathogenesis. However, understanding of cAMP signaling pathways is...

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Publicado en:Mol Microbiol
Main Authors: Johnson, Richard M., Bai, Guangchun, DeMott, Christopher M., Banavali, Nilesh K., Montague, Christine R., Moon, Caroline, Shekhtman, Alexander, VanderVen, Brian, McDonough, Kathleen A.
Formato: Artigo
Idioma:Inglês
Publicado: 2017
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Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC5499149/
https://ncbi.nlm.nih.gov/pubmed/28464471
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/mmi.13701
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