RNA Nanoparticle-Based Targeted Therapy for Glioblastoma through Inhibition of Oncogenic miR-21

Targeted inhibition of oncogenic miRNA-21 has been proposed to treat glioblastoma by rescuing tumor suppressors, PTEN and PDCD4. However, systemic delivery of anti-miR-21 sequences requires a robust and efficient delivery platform to successfully inhibit this druggable target. Three-way-junction (3W...

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Detalhes bibliográficos
Publicado no:Mol Ther
Main Authors: Lee, Tae Jin, Yoo, Ji Young, Shu, Dan, Li, Hui, Zhang, Jianying, Yu, Jun-Ge, Jaime-Ramirez, Alena Cristina, Acunzo, Mario, Romano, Giulia, Cui, Ri, Sun, Hui-Lung, Luo, Zhenghua, Old, Matthew, Kaur, Balveen, Guo, Peixuan, Croce, Carlo M.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society of Gene & Cell Therapy 2017
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Original Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5498802/
https://ncbi.nlm.nih.gov/pubmed/28109960
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ymthe.2016.11.016
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