Mouse Models of C9orf72 Hexanucleotide Repeat Expansion in Amyotrophic Lateral Sclerosis/ Frontotemporal Dementia

The presence of hexanucleotide repeat expansion (HRE) in the first intron of the human C9orf72 gene is the most common genetic cause underlying both familial amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD). Studies aimed at elucidating the pathogenic mechanisms associated of C9...

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Bibliographic Details
Published in:Front Cell Neurosci
Main Authors: Batra, Ranjan, Lee, Chris W.
Format: Artigo
Language:Inglês
Published: Frontiers Media S.A. 2017
Subjects:
Neuroscience
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC5498553/
https://ncbi.nlm.nih.gov/pubmed/28729824
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fncel.2017.00196
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