V1V2-specific complement activating serum IgG as a correlate of reduced HIV-1 infection risk in RV144

Non-neutralizing IgG to the V1V2 loop of HIV-1 gp120 correlates with a decreased risk of HIV-1 infection but the mechanism of protection remains unknown. This V1V2 IgG correlate was identified in RV144 Thai trial vaccine recipients, who were primed with a canarypox vector expressing membrane-bound g...

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Détails bibliographiques
Publié dans:PLoS One
Auteurs principaux: Perez, Lautaro G., Martinez, David R., deCamp, Allan C., Pinter, Abraham, Berman, Phillip W., Francis, Donald, Sinangil, Faruk, Lee, Carter, Greene, Kelli, Gao, Hongmei, Nitayaphan, Sorachai, Rerks-Ngarm, Supachai, Kaewkungwal, Jaranit, Pitisuttithum, Punnee, Tartaglia, James, O’Connell, Robert J., Robb, Merlin L., Michael, Nelson L., Kim, Jerome H., Gilbert, Peter, Montefiori, David C.
Format: Artigo
Langue:Inglês
Publié: Public Library of Science 2017
Sujets:
Research Article
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC5498072/
https://ncbi.nlm.nih.gov/pubmed/28678869
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0180720
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