Targeting ABL-IRE1α signaling spares ER-stressed pancreatic β-cells to reverse autoimmune diabetes

In cells experiencing unrelieved endoplasmic reticulum (ER) stress, the ER transmembrane kinase/endoribonuclease (RNase)—IRE1α—endonucleolytically degrades ER-localized mRNAs to promote apoptosis. Here we find that the ABL family of tyrosine kinases rheostatically enhances IRE1α’s enzymatic activiti...

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Detaylı Bibliyografya
Yayımlandı:Cell Metab
Asıl Yazarlar: Morita, Shuhei, Villalta, S. Armando, Feldman, Hannah, Register, Ames C., Rosenthal, Wendy, Hoffmann-Petersen, Ingeborg T., Mehdizadeh, Morvarid, Ghosh, Rajarshi, Wang, Likun, Colon-Negron, Kevin, Meza-Acevedo, Rosa, Backes, Bradley J., Maly, Dustin J., Bluestone, Jeffrey A., Papa, Feroz R.
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: 2017
Konular:
Article
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC5497784/
https://ncbi.nlm.nih.gov/pubmed/28380378
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.cmet.2017.03.018
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