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Antitumor activity and pharmacologic characterization of the depsipeptide analog as a novel histone deacetylase/ phosphatidylinositol 3‐kinase dual inhibitor

Histone deacetylase (HDAC)/phosphatidylinositol 3‐kinase (PI3K) dual inhibition is a promising strategy for the treatment of intractable cancers because of the advantages of overcoming potential resistance and showing synergistic effects. Therefore, development of an HDAC/PI3K dual inhibitor is reas...

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Vydáno v:Cancer Sci
Hlavní autoři: Saijo, Ken, Imai, Hiroo, Chikamatsu, Sonoko, Narita, Koichi, Katoh, Tadashi, Ishioka, Chikashi
Médium: Artigo
Jazyk:Inglês
Vydáno: John Wiley and Sons Inc. 2017
Témata:
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC5497724/
https://ncbi.nlm.nih.gov/pubmed/28406576
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/cas.13255
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