Pyruvate kinase inhibits proliferation during postnatal cerebellar neurogenesis and suppresses medulloblastoma formation

Aerobic glycolysis supports proliferation through unresolved mechanisms. We have previously shown that aerobic glycolysis is required for the regulated proliferation of cerebellar granule neuron progenitors (CGNPs), and for the growth of CGNP-derived medulloblastoma. Blocking the initiation of glyco...

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Publicado no:Cancer Res
Main Authors: Tech, Katherine, Tikunov, Andrey P., Farooq, Hamza, Morrissy, A. Sorana, Meidinger, Jessica, Fish, Taylor, Green, Sarah C., Liu, Hedi, Li, Yisu, Mungall, Andrew J., Moore, Richard A., Ma, Yussanne, Jones, Steven J.M., Marra, Marco A., Vander Heiden, Matthew G., Taylor, Michael D., Macdonald, Jeffrey M., Gershon, Timothy R.
Formato: Artigo
Idioma:Inglês
Publicado em: 2017
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5497486/
https://ncbi.nlm.nih.gov/pubmed/28515149
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/0008-5472.CAN-16-3304
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