Pyruvate kinase inhibits proliferation during postnatal cerebellar neurogenesis and suppresses medulloblastoma formation

Aerobic glycolysis supports proliferation through unresolved mechanisms. We have previously shown that aerobic glycolysis is required for the regulated proliferation of cerebellar granule neuron progenitors (CGNPs), and for the growth of CGNP-derived medulloblastoma. Blocking the initiation of glyco...

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Bibliografiska uppgifter
I publikationen:Cancer Res
Huvudupphovsmän: Tech, Katherine, Tikunov, Andrey P., Farooq, Hamza, Morrissy, A. Sorana, Meidinger, Jessica, Fish, Taylor, Green, Sarah C., Liu, Hedi, Li, Yisu, Mungall, Andrew J., Moore, Richard A., Ma, Yussanne, Jones, Steven J.M., Marra, Marco A., Vander Heiden, Matthew G., Taylor, Michael D., Macdonald, Jeffrey M., Gershon, Timothy R.
Materialtyp: Artigo
Språk:Inglês
Publicerad: 2017
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Article
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC5497486/
https://ncbi.nlm.nih.gov/pubmed/28515149
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/0008-5472.CAN-16-3304
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