Data driven polypharmacological drug design for lung cancer: analyses for targeting ALK, MET, and EGFR

Drug design of protein kinase inhibitors is now greatly enabled by thousands of publicly available X-ray structures, extensive ligand binding data, and optimized scaffolds coming off patent. The extensive data begin to enable design against a spectrum of targets (polypharmacology); however, the data...

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Vydáno v:J Cheminform
Hlavní autoři: Narayanan, Dilip, Gani, Osman A. B. S. M., Gruber, Franz X. E., Engh, Richard A.
Médium: Artigo
Jazyk:Inglês
Vydáno: Springer International Publishing 2017
Témata:
Research Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC5496928/
https://ncbi.nlm.nih.gov/pubmed/29086093
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s13321-017-0229-8
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