Toll-like receptor 4 stimulation with monophosphoryl lipid A ameliorates motor deficits and nigral neurodegeneration triggered by extraneuronal α-synucleinopathy

BACKGROUND: Alpha-synuclein (α-syn) aggregation represents the pathological hallmark of α-synucleinopathies like Parkinson’s disease (PD), dementia with Lewy bodies (DLB), and multiple system atrophy (MSA). Toll-like receptors (TLRs) are a family of highly conserved molecules that recognize pathogen...

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Publicat a:Mol Neurodegener
Autors principals: Venezia, Serena, Refolo, Violetta, Polissidis, Alexia, Stefanis, Leonidas, Wenning, Gregor K., Stefanova, Nadia
Format: Artigo
Idioma:Inglês
Publicat: BioMed Central 2017
Matèries:
Research Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC5496237/
https://ncbi.nlm.nih.gov/pubmed/28676095
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s13024-017-0195-7
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