Selinexor Overcomes Hypoxia-Induced Drug Resistance in Multiple Myeloma

Increased levels of the nuclear export protein, exportin 1 (XPO1), were demonstrated in multiple myeloma (MM) patients. Targeting XPO1 with selinexor (the selective inhibitor of nuclear export; SINE compound KPT-330) demonstrates broad antitumor activity also in patient cells resistant to bortezomib...

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Detalhes bibliográficos
Publicado no:Transl Oncol
Main Authors: Muz, Barbara, Azab, Feda, de la Puente, Pilar, Landesman, Yosef, Azab, Abdel Kareem
Formato: Artigo
Idioma:Inglês
Publicado em: Neoplasia Press 2017
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Original article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5496204/
https://ncbi.nlm.nih.gov/pubmed/28668761
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.tranon.2017.04.010
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