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Selinexor Overcomes Hypoxia-Induced Drug Resistance in Multiple Myeloma
Increased levels of the nuclear export protein, exportin 1 (XPO1), were demonstrated in multiple myeloma (MM) patients. Targeting XPO1 with selinexor (the selective inhibitor of nuclear export; SINE compound KPT-330) demonstrates broad antitumor activity also in patient cells resistant to bortezomib...
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| 發表在: | Transl Oncol |
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| Main Authors: | , , , , |
| 格式: | Artigo |
| 語言: | Inglês |
| 出版: |
Neoplasia Press
2017
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| 主題: | |
| 在線閱讀: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5496204/ https://ncbi.nlm.nih.gov/pubmed/28668761 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.tranon.2017.04.010 |
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