The ubiquitin–protein ligase Itch regulates p73 stability

p73, a member of the p53 family of transcription factors, is upregulated in response to DNA damage, inducing cell cycle arrest and apoptosis. Besides indications that this p73 response is post-transcriptional, little is known about the underlying molecular mechanisms of p73 protein degradation. Ubiq...

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Veröffentlicht in:	EMBO J
Hauptverfasser:	Rossi, Mario, De Laurenzi, Vincenzo, Munarriz, Eliana, Green, Douglas R, Liu, Yun-Cai, Vousden, Karen H, Cesareni, Gianni, Melino, Gerry
Format:	Artigo
Sprache:	Inglês
Veröffentlicht:	Nature Publishing Group 2005
Schlagworte:	Article
Online-Zugang:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC549609/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/15678106/ https://ncbi.nlm.nih.govhttps://doi.org/10.1038/sj.emboj.7600444
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The ubiquitin–protein ligase Itch regulates p73 stability

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