Inhibiting glucosylceramide synthase exacerbates cisplatin-induced acute kidney injury

Acute kidney injury (AKI), resulting from chemotherapeutic agents such as cisplatin, remains an obstacle in the treatment of cancer. Cisplatin-induced AKI involves apoptotic and necrotic cell death, pathways regulated by sphingolipids such as ceramide and glucosylceramide. Results from this study in...

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Bibliographic Details
Published in:J Lipid Res
Main Authors: Dupre, Tess V., Doll, Mark A., Shah, Parag P., Sharp, Cierra N., Siow, Deanna, Megyesi, Judit, Shayman, James, Bielawska, Alicja, Bielawski, Jacek, Beverly, Levi J., Hernandez-Corbacho, Maria, Clarke, Christopher J., Snider, Ashley J., Schnellmann, Rick G., Obeid, Lina M., Hannun, Yusuf A., Siskind, Leah J.
Format: Artigo
Language:Inglês
Published: The American Society for Biochemistry and Molecular Biology 2017
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Research Articles
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC5496040/
https://ncbi.nlm.nih.gov/pubmed/28490444
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1194/jlr.M076745
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