Free actin impairs macrophage bacterial defenses via scavenger receptor MARCO interaction with reversal by plasma gelsolin

Lung injury can release intracellular actin into the alveolar milieu and is also associated with increased susceptibility to secondary infections. We investigated the effect of free (extracellular) actin on lung macrophage host defense functions. Western blot analysis demonstrated free actin release...

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Publicat a:Am J Physiol Lung Cell Mol Physiol
Autors principals: Ordija, Christine M., Chiou, Terry Ting-Yu, Yang, Zhiping, Deloid, Glen M., de Oliveira Valdo, Melina, Wang, Zhi, Bedugnis, Alice, Noah, Terry L., Jones, Samuel, Koziel, Henry, Kobzik, Lester
Format: Artigo
Idioma:Inglês
Publicat: American Physiological Society 2017
Matèries:
Research Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC5495953/
https://ncbi.nlm.nih.gov/pubmed/28385809
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1152/ajplung.00067.2017
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