Free actin impairs macrophage bacterial defenses via scavenger receptor MARCO interaction with reversal by plasma gelsolin

Lung injury can release intracellular actin into the alveolar milieu and is also associated with increased susceptibility to secondary infections. We investigated the effect of free (extracellular) actin on lung macrophage host defense functions. Western blot analysis demonstrated free actin release...

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Опубликовано в: :Am J Physiol Lung Cell Mol Physiol
Главные авторы: Ordija, Christine M., Chiou, Terry Ting-Yu, Yang, Zhiping, Deloid, Glen M., de Oliveira Valdo, Melina, Wang, Zhi, Bedugnis, Alice, Noah, Terry L., Jones, Samuel, Koziel, Henry, Kobzik, Lester
Формат: Artigo
Язык:Inglês
Опубликовано: American Physiological Society 2017
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Research Article
Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC5495953/
https://ncbi.nlm.nih.gov/pubmed/28385809
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1152/ajplung.00067.2017
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