Free actin impairs macrophage bacterial defenses via scavenger receptor MARCO interaction with reversal by plasma gelsolin

Lung injury can release intracellular actin into the alveolar milieu and is also associated with increased susceptibility to secondary infections. We investigated the effect of free (extracellular) actin on lung macrophage host defense functions. Western blot analysis demonstrated free actin release...

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Detalhes bibliográficos
Publicado no:Am J Physiol Lung Cell Mol Physiol
Main Authors: Ordija, Christine M., Chiou, Terry Ting-Yu, Yang, Zhiping, Deloid, Glen M., de Oliveira Valdo, Melina, Wang, Zhi, Bedugnis, Alice, Noah, Terry L., Jones, Samuel, Koziel, Henry, Kobzik, Lester
Formato: Artigo
Idioma:Inglês
Publicado em: American Physiological Society 2017
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5495953/
https://ncbi.nlm.nih.gov/pubmed/28385809
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1152/ajplung.00067.2017
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