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RORα-dependent type 2 innate lymphoid cells are required and sufficient for mucous metaplasia in immature mice

Early-life wheezing-associated respiratory tract infection by rhinovirus (RV) is considered a risk factor for asthma development. We have shown that RV infection of 6-day-old BALB/c mice, but not mature mice, induces an asthmalike phenotype that is associated with an increase in the population of ty...

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Опубликовано в: :Am J Physiol Lung Cell Mol Physiol
Главные авторы: Rajput, Charu, Cui, Tracy, Han, Mingyuan, Lei, Jing, Hinde, Joanna L., Wu, Qian, Bentley, J. Kelley, Hershenson, Marc B.
Формат: Artigo
Язык:Inglês
Опубликовано: American Physiological Society 2017
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Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC5495952/
https://ncbi.nlm.nih.gov/pubmed/28360114
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1152/ajplung.00368.2016
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