IFN-γ Blocks Development of an Asthma Phenotype in Rhinovirus-Infected Baby Mice by Inhibiting Type 2 Innate Lymphoid Cells

Early-life wheezing-associated infections with rhinovirus (RV) have been associated with asthma development in children. We have shown that RV infection of 6-day-old mice induces mucous metaplasia and airways hyperresponsiveness, which is dependent on IL-13, IL-25, and type 2 innate lymphoid cells (...

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Publicado en:Am J Respir Cell Mol Biol
Autores principales: Han, Mingyuan, Hong, Jun Young, Jaipalli, Suraj, Rajput, Charu, Lei, Jing, Hinde, Joanna L., Chen, Qiang, Hershenson, Natalie M., Bentley, J. Kelley, Hershenson, Marc B.
Formato: Artigo
Lenguaje:Inglês
Publicado: American Thoracic Society 2017
Materias:
Original Research
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC5359646/
https://ncbi.nlm.nih.gov/pubmed/27679954
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1165/rcmb.2016-0056OC
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