Myristoylated rhinovirus VP4 protein activates TLR2-dependent proinflammatory gene expression

Asthma exacerbations are often caused by rhinovirus (RV). We and others have shown that Toll-like receptor 2 (TLR2), a membrane surface receptor that recognizes bacterial lipopeptides and lipoteichoic acid, is required and sufficient for RV-induced proinflammatory responses in vitro and in vivo. We...

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Vydáno v:Am J Physiol Lung Cell Mol Physiol
Hlavní autoři: Bentley, J. Kelley, Han, Mingyuan, Jaipalli, Suraj, Hinde, Joanna L., Lei, Jing, Ishikawa, Tomoko, Goldsmith, Adam M., Rajput, Charu, Hershenson, Marc B.
Médium: Artigo
Jazyk:Inglês
Vydáno: American Physiological Society 2019
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Research Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC6689742/
https://ncbi.nlm.nih.gov/pubmed/30908938
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1152/ajplung.00365.2018
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