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Reduced membrane cholesterol limits pulmonary endothelial Ca(2+) entry after chronic hypoxia

Chronic hypoxia (CH)-induced pulmonary hypertension is associated with diminished production of endothelium-derived Ca(2+)-dependent vasodilators such as nitric oxide. Interestingly, ATP-induced endothelial Ca(2+) entry as well as membrane cholesterol (Chol) are decreased in pulmonary arteries from...

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Vydáno v:Am J Physiol Heart Circ Physiol
Hlavní autoři: Zhang, Bojun, Naik, Jay S., Jernigan, Nikki L., Walker, Benjimen R., Resta, Thomas C.
Médium: Artigo
Jazyk:Inglês
Vydáno: American Physiological Society 2017
Témata:
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC5495930/
https://ncbi.nlm.nih.gov/pubmed/28364016
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1152/ajpheart.00097.2017
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